Mission
My laboratory concentrates on the roles that the SIBLING family of small integrin-binding proteins play in normal and diseased tissues. The SIBLING family currently includes: bone sialoprotein (BSP encoded by the gene IBSP), dentin matrix protein-1 (DMP1), dentin sialophosphoprotein (DSPP), matrix extracellular phosphoglycoprotein (MEPE), and osteopontin (OPN, encoded by SPPI gene). The genes are a tandem cluster on human chromosome 4 (mouse 5). Although first thought to be specific for bones and teeth, the SIBLNGs are also expressed in normal, metabolically active ductal epithelial cells and are highly up-regulated in many cancers.
Recent Publications:
Bellahcène A, Castronovo V, Ogbureke KU, Fisher LW, Fedarko NS. Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat Rev Cancer. 2008 Mar;8(3):212-26. PMID: PMID: 18292776
Fantner GE, Adams J, Turner P, Thurner PJ, Fisher LW, Hansma PK. Nanoscale ion mediated networks in bone: osteopontin can repeatedly dissipate large amounts of energy. Nano Lett. 2007 Aug;7(8):2491-8. PMID: 17645366
Ogbureke KU, Nikitakis NG, Warburton G, Ord RA, Sauk JJ, Waller JL, Fisher LW. Up-regulation of SIBLING proteins and correlation with cognate MMP expression in oral cancer. Oral Oncol. 2007 Oct;43(9):920-32. PMID: 17306612
Ogbureke KU, Fisher LW. SIBLING expression patterns in duct epithelia reflect the degree of metabolic activity. J Histochem Cytochem. 2007 Apr;55(4):403-9. PMID: 17210923
Nam JS, Suchar AM, Kang MJ, Stuelten CH, Tang B, Michalowska AM, Fisher LW, Fedarko NS, Jain A, Pinkas J, Lonning S, Wakefield LM. Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer. Cancer Res. 2006 Jun 15;66(12):6327-35. PMID: 16778210
Karadag A, Fedarko NS, Fisher LW. Dentin matrix protein 1 enhances invasion potential of colon cancer cells by bridging matrix metalloproteinase-9 to integrins and CD44. Cancer Res. 2005 Dec 15;65(24):11545-52. PMID: 16357164
Chaplet M, Waltregny D, Detry C, Fisher LW, Castronovo V, Bellahcène A. Expression of dentin sialophosphoprotein in human prostate cancer and its correlation with tumor aggressiveness. Int J Cancer. 2006 Feb 15;118(4):850-6. PMID: 16108038
Ogbureke KU, Fisher LW. Renal expression of SIBLING proteins and their partner matrix metalloproteinases (MMPs). Kidney Int. 2005 Jul;68(1):155-66. PMID: 15954904
Fisher LW, Jain A, Tayback M, Fedarko NS. Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers. Clin Cancer Res. 2004 Dec 15;10(24):8501-11. PMID: 15623631
Ogbureke KU, Fisher LW. Expression of SIBLINGs and their partner MMPs in salivary glands. J Dent Res. 2004 Sep;83(9):664-70. PMID: 15329369
Fedarko NS, Jain A, Karadag A, Fisher LW. Three small integrin binding ligand N-linked glycoproteins (SIBLINGs) bind and activate specific matrix metalloproteinases. FASEB J. 2004 Apr;18(6):734-6. PMID: 14766790
Most of our publications can be found in PDF format in our department's online archives.
